Marvel notoriously did it with Spider-Man and Mary Jane Watson. Will DC go through with ending Superman's marriage to Lois Lane as part of its impending reboot of its whole line?
One might question whether the marriage made sense in the first place. That could be discussed at a number of levels. But expect a lot of fans who liked it or even grew up with it to be expressing their dismay. Marvel is still copping flak years later over the Spider-Man/MJ thing.
Now that's a marriage initiative to support!
(Yes, I'm kidding with my last comment... but only kinda half kidding.)