Allow me to point you to the newest attempt by Sam Harris to derive "ought" from "is".
I don't want to spend another week bogged down with this issue, so I'm not going to say much, especially since my original criticism was not so much that he purports to derive "ought" from "is" as that he fails to show that morality is objective in the sense discussed in contemporary metaethics. It might, however, be plausibly suggested that these are two sides of the same thing - indeed, I think they are.
However, the trick was always to derive "ought", in the sense of having reasons, from "is" statements that say nothing about what any being desires, fears, hopes for, wants, aims at, values, etc. Once you introduce something about those psychological phenomena, deriving "ought" from "is" is very easy. Even without those phenomena, you can say that someone "ought to" act in a way relative to an institutional standard, such as the current standards of law, etiquette, fashion, or a system of positive morality. No one denies that all these sorts of oughts and derivations of "ought" are possible.
So yes, there are various well-known ways to derive "ought" from "is". You can also do the job if you redefine "ought" so that it is no longer about having reasons for action, but about actions that conform to a stipulated definition of "good", e.g. we apply the word "good" to actions that produce pleasure or eudaimonia. But that's just cheating. Worse, your opponent can say, without making any mistakes: "I accept that Action X is 'good' by your definition, and that I therefore 'ought' to do it by your definitions of 'good' and 'ought'. But what's that to me?. You still haven't given me a reason, acceptable to me, for me to do it."
The trick is to avoid cheating with stipulative definitions and to avoid relying on human psychology or human institutions. You are supposed to derive that I really, really ought to do X without relying on any of those short-cuts. That is the sort of derivation that so many people want, as it's a derivation that will transcend subjectivity or semantics or culture. If you do the job, you've made normativity "objective".
Some people think that they can do the job by relying on the (alleged) commands of God, but that turns out to have fundamental problems. Kantians/moral rationalists (such as Nagel and Korsgaard) think they can rely on an exercise of pure reason without appealing to any contingent psychological phenomena, but I don't believe they've ever succeeded. In fact, I don't believe that the job can be done.